DHA-EE Research

Summary Questions About DHA-EE in Zellweger’s


Modulation of inflammation in brain: a matter of fat

Akhlaq A. Farooqui , Lloyd A. Horrocks, Tahira Farooqui

Journal of Neurochemistry, January 25, 2007



Essential Dietary Bioactive Lipids in Neuroinflammatory Diseases. Antioxid Redox Signal.

Catani MV, Gasperi V, Bisogno T, Maccarrone M.

2018;29(1):37–60. doi:10.1089/ars.2016.6958




Dra. Manuela Martinez‘ last published research, 2010.  The Δ4-desaturation pathway for

DHA biosynthesis is operative in the human species: Differences between normal controls

and children with the Zellweger syndrome. Martinez et al. Lipids in Health and Disease 2010,

9:98 http://www.lipidworld.com/content/9/1/98



Docosahexaenoic acid mediates peroxisomal elongation, a prerequisite for peroxisome division.

(2-2012)  http://jcs.biologists.org/content/125/3/589.long#T1


DHA is a key factor in stimulating brain-derived neurotrophic factor (BDNF)





Noguer Visual Follow-Up in Peroxisomal-Disorder Patients Treated with Docosahexaenoic Acid

Ethyl Ester  http://www.ncbi.nlm.nih.gov/pubmed/19933185


Martínez, Manuela, et al. “Therapeutic effects of docosahexaenoic acid ethyl ester in patients with

generalized peroxisomal disorders.” The American Journal of Clinical Nutrition 71.1 (2000):

376s-385s.    http://www.ncbi.nlm.nih.gov/pubmed/10618001



Zellweger’s Syndrome Restoring the DHA Levels in the Brains of Zellweger Patients, J Mol Neurosci.

2001 Apr-Jun;16(2-3):309-16  http://www.ncbi.nlm.nih.gov/pubmed/11478386


The fundamentals and practice of docosahexaenoic acid therapy in peroxisomal disorders, by M

Martinez – ‎2000.  Current Opinion in Clinical Nutrition & Metabolic Care: March 2000 – Volume 3 –

Issue 2 – pp 101-108.


Peroxisomal disorders and their treatment.



Two Studies, Two Products, Two Results  Investigates the difference in the Martinez studies and the Paker, et al. study.



Enfermedades peroxisomales generalizadas: nuevas posibilidades terapeuticas, Martinez Cap 44;

Enfermedades peroxisomales generalizadas: nuevo enfoque terapeutico, Cap.+68.+Dra.+Martinez;